Communications

Kinase challenge: BioSight pinpoints Kinase from all ATP-binding proteins.

SUMMARY BioSight* is the BIONEXT’s Web interface allowing the retrieval and assessment of local surface similarities. Here, BioSight was challenged with two serine/threonine kinase binding pockets. Top ranked proteins are mainly kinases, of course. But some other relevant proteins, not belonging to the kinase family, are easily found by BioSight. These data could help unravel parts the pharmacological profile for some kinase inhibitors. (*) Create your profile on BioSight, the fully secured Web access to BioBind, to access the full analysis

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BioSight targets it rightly - Structural homology and beyond in E. Coli DHODH

SUMMARY BioSight* is a BIONEXT’s web platform dedicated to the retrieval and assessment of local surface similarities. Here, BioSight was challenged on a structure of the protein E. coli dihydroorotate dehydrogenase (E. coli DHODH) complexed with orotate. Among the first hits retrieved were legitimate DHODH homologs and also the similarly folded dihydropyrimidine dehydrogenase. Surprisingly, the molybdenum storage protein was also significantly highly ranked by BioSight despite its structural differences with the DHODH query.

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BiovizJS: a versatile 3D molecular visualizer anywhere, anytime and with any device

SUMMARY Structural properties and physicochemical interactions are of critical interest when studying biomolecules. Therefore, BIONEXT has developed BiovizJS, a 3D molecular visualization Web application runnable on any network connected device. This tool provides both improved and exclusive features for molecular visualization with the aim to enhance your experience in many situations and from any devices. In order to ease its integration into your website, it provides a straightforward API.

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