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BioSight targets it rightly - Structural homology and beyond in E. Coli DHODH

on August 23, 2017

SUMMARY BioSight* is a BIONEXT’s web platform dedicated to the retrieval and assessment of local surface similarities. Here, BioSight was challenged on a structure of the protein E. coli dihydroorotate dehydrogenase (E. coli DHODH) complexed with orotate. Among the first hits retrieved were legitimate DHODH homologs and also the similarly folded dihydropyrimidine dehydrogenase. Surprisingly, the molybdenum storage protein was also significantly highly ranked by BioSight despite its structural differences with the DHODH query.

Bionext wants to raise 5 million for the commercialization of its new service

on August 21, 2017

Press Release from Le Journal des Entreprises Bionext, a French biotechnology company located in Strasbourg, has just launched a Web platform dedicated to pharmaceutical research and now ambitions to raise five million for its commercialization. See more: Source

BiovizJS: a versatile 3D molecular visualizer anywhere, anytime and with any device

on August 14, 2017

SUMMARY Structural properties and physicochemical interactions are of critical interest when studying biomolecules. Therefore, BIONEXT has developed BiovizJS, a 3D molecular visualization Web application runnable on any network connected device. This tool provides both improved and exclusive features for molecular visualization with the aim to enhance your experience in many situations and from any devices. In order to ease its integration into your website, it provides a straightforward API.

Fit for fitting: BIONEXT-DSS, a dataset of similar sites

on July 25, 2017

SUMMARY Predicting novel binding pockets for a given medicine is a challenging task with numerous pharmaceutical applications. Based on the principle that “similar binding sites share similar ligands”1, many binding pocket prediction algorithms are based on the evaluation and retrieval of pockets being similar to a known binding site. Two distinct yet connected problematics can hence be described: (i) the ability to retrieve known sites for a given ligand in distinct proteins, and (ii) the retrieval of similar sites.

Learn about BioSight, our main product

BioSight Target Analysis is dedicated to the retrieval of common patterns at the surface of macromolecules. Based on a user defined query pattern, Target Analysis iterates over a large database of structures and identifies at the surface of these macromolecules areas that are similar to the query.

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